생명공학대학 - 생명공학대학

  • 교수 식품생화학, 식품면역학
  • 박계원

관심분야

지방세포의 에너지 대사 촉진을 통한 비만 치료 기술 연구 
천연물의 비만 및 대사질환에 대한 유효성 평가 및 기전연구 
분자적 기전 연구를 통한 신규 표적 발굴 연구

학력

  • 2004년 University of Utah 박사학위 취득

약력/경력

  • UCLA 병리학연구실 박사후연구원(2005 - 2009)
  • 유타대 분자생물학 과정 연구원 (2004 -2005)

학술지 논문

  • (2022)  Butein Ameliorates Oxidative Stress in H9c2 Cardiomyoblasts through Activation of the NRF2 Signaling Pathway.  ANTIOXIDANTS.  11,  8
  • (2021)  Butein-Enriched Fractions of Butea monosperma (Lam.) Taub. Flower Decrease Weight Gains and Increase Energy Expenditure in High-Fat Diet-Induced Obese Mice.  JOURNAL OF MEDICINAL FOOD.  24,  12
  • (2021)  A Role of Stress Sensor Nrf2 in Stimulating Thermogenesis and Energy Expenditure.  BIOMEDICINES.  9,  9
  • (2021)  Nrf2 induces Ucp1 expression in adipocytes in response to beta 3-AR stimulation and enhances oxygen consumption in high-fat diet-fed obese mice.  BMB REPORTS.  54,  8
  • (2020)  Sesamol Increases Ucp1 Expression in White Adipose Tissues and Stimulates Energy Expenditure in High-Fat Diet-Fed Obese Mice.  NUTRIENTS.  12,  5
  • (2019)  Identification of Phf16 and Pnpla3 as new adipogenic factors regulated by phytochemicals.  JOURNAL OF CELLULAR BIOCHEMISTRY.  120,  3
  • (2019)  Mechanisms underlying UCP1 dependent and independent adipocyte thermogenesis.  OBESITY REVIEWS.  20,  2
  • (2019)  Oxyresveratrol Increases Energy Expenditure through Foxo3a-Mediated Ucp1 Induction in High-Fat-Diet-Induced Obese Mice.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.  20(1),  26
  • (2019)  Sulfuretin Prevents Obesity and Metabolic Diseases in Diet Induced Obese Mice.  BIOMOLECULES & THERAPEUTICS.  27,  1
  • (2018)  Atf3 induction is a therapeutic target for obesity and metabolic diseases.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.  504,  4
  • (2018)  PI3Ka-Akt1-mediated Prdm4 induction in adipose tissue increases energy expenditure, inhibits weight gain, and improves insulin resistance in diet-induced obese mice.  CELL DEATH & DISEASE.  9,  9
  • (2017)  Induction of thermogenic adipocytes: molecular targets and thermogenic small molecules.  EXPERIMENTAL AND MOLECULAR MEDICINE.  49, 
  • (2016)  Small Molecule-Induced Complement Factor D (Adipsin) Promotes Lipid Accumulation and Adipocyte Differentiation.  PLOS ONE.  11,  9
  • (2016)  Prdm4 induction by the small molecule butein promotes white adipose tissue browning.  NATURE CHEMICAL BIOLOGY.  12,  7
  • (2016)  B cell translocation gene 2 (Btg2) is regulated by Stat3 signaling and inhibits adipocyte differentiation.  MOLECULAR AND CELLULAR BIOCHEMISTRY.  413,  1-2
  • (2016)  Notch1 deficiency decreases hepatic lipid accumulation by induction of fatty acid oxidation.  SCIENTIFIC REPORTS.  6,  19377
  • (2016)  Antiadipogenic and proosteogenic effects of luteolin, a major dietary flavone, are mediated by the induction of DnaJ (Hsp40) Homolog, Subfamily B, Member 1.  JOURNAL OF NUTRITIONAL BIOCHEMISTRY.  30,  1
  • (2015)  Aqueous extracts of hulled barley containing coumaric acid and ferulic acid inhibit adipogenesis in vitro and obesity in vivo.  JOURNAL OF FUNCTIONAL FOODS.  12, 
  • (2015)  Sulfuretin induces osteoblast differentiation through activation of TGF-beta signaling.  MOLECULAR AND CELLULAR BIOCHEMISTRY.  410,  1-2
  • (2015)  miR-195a Inhibits Adipocyte Differentiation by Targeting the Preadipogenic Determinator Zfp423.  JOURNAL OF CELLULAR BIOCHEMISTRY.  116,  11

특허/프로그램

  • COMPOSITION FOR INDUCING DIFFERENTIATION INTO BEIGE AND BROWN ADIPOCYTES AND METHOD OF INDUCING THE SAME.  14/745.772.  20170124.  미국